Authorities said DJ Megatron was shot in the chest while resisting robbers near his Staten Island home in March 2011.
Police arrested 21-year-old William Williams and 20-year-old Richard Cromwell on Wednesday.
Police said McGriff was shot once in the chest. They are investigating whether drugs played a role in his death, but said Monday they do not believe it was a robbery.
Urban radio and TV personality DJ Megatron was shot to death in New York City early Sunday morning near his Staten Island home.