VERNON, Conn. (CBSNewYork) — Seven people were rushed to the hospital Thursday after a house explosion in northern Connecticut.

The incident happened around 4:15 p.m. in a home on East Street in Vernon, just east of Hartford, CBS affiliate WFSB-TV reported.

The home was completely destroyed.

Four people had to be rescued from the home, while two made it out on their own, WFSB reported.

Four children were taken to Connecticut Children’s Medical Center in Hartford on Thursday, all of them under the age of 16, WFSB reported.

A 7-year-old boy was reported, in serious condition with significant injuries, and a 15-year-old girl was also hospitalized, WFSB reported.

Two other girls, ages 11 and 12, were also hospitalized after being found outside the home when first responders arrived, WFSB reported.

A 23-year-old man and a 35-year-old woman were taken to Hartford Hospital in Hartford and were listed in critical condition, WFSB reported. A 60-year-old man was also found outside the home, but declined medical treatment, WFSB reported.

The cause of the blast remained under investigation late Thursday.