WASHINGTON (CBSNewYork/AP) — President Donald Trump on Sunday condemned a “mindless CHEMICAL attack” in Syria that killed women and children, called Syrian President Bashar Assad an “animal” and delivered a rare personal criticism of Russian President Vladimir Putin for supporting the Damascus government.

As Washington worked to verify the claim by Syrian opposition activists and rescuers that poison gas was used, Trump said there would be a “big price to pay” for resorting to outlawed weapons of mass destruction. A top White House aide, asked about the possibility of a U.S. missile strike in response, said, “I wouldn’t take anything off the table.”

Just over a year ago, Trump ordered dozens of cruise missiles to be fired at a Syrian air base after declaring there was no doubt Assad had “choked out the lives of helpless” civilians in an attack that used banned gases. White House advisers said at the time that images of hurt children helped spur the president to launch that air strike, and television new shows on Sunday aired similar depictions of suffering young Syrians.

Syrian opposition activists and rescuers said Sunday that a poison gas attack on a rebel-held town near the capital killed at least 40 people. President Bashar Assad’s government is denying the allegations of such an attack near Damascus.

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The alleged attack in the town of Douma occurred late Saturday amid a resumed offensive by Syrian government forces after the collapse of a truce with the Army of Islam rebel group.

The reports could not be independently verified.

Trump says in a tweet Sunday that the “area of atrocity is in lockdown and encircled by Syrian Army, making it completely inaccessible to outside world.” He says Russian President Vladimir Putin and Iran — influential Syrian backers — “are responsible for backing Animal Assad.”

First responders said they found families suffocated in their homes and shelters, with foam on their mouths. The opposition-linked Syrian Civil Defense were able to document 42 fatalities but were impeded from searching further by strong odors that gave their rescuers difficulties breathing, said Siraj Mahmoud, a spokesman for the group, which is known as the White Helmets.

Government forces agreed to a two-hour cease-fire in Douma on Sunday after the Army of Islam asked to restart talks to end the assault, according to the state-affiliated al-Ikhbariya TV station.

Douma has been devastated by close to five years of siege at the hands of government forces. It was once one of the hubs of the 2011 Arab Spring-styled uprising against President Bashar Assad’s government.

In recent weeks, government forces have recaptured villages and towns in the eastern Ghouta suburbs of the capital. Douma is the only town left holding out.

The government demanded that the Army of Islam release prisoners and stops their shelling of Damascus as a precondition to resuming talks, according to al-Ikhbariya. The station said government negotiators met with a delegation of rebels at a checkpoint outside Douma.

A joint statement by the Civil Defense and the Syrian American Medical Society, a relief organization, said that more than 500 people, mostly women and children, were brought to medical centers with difficulty breathing, foaming at the mouth, and burning sensations in the eyes. It said patients gave off a chlorine-like smell. Some had bluish skin, a sign of oxygen deprivation.

It said the symptoms were consistent with chemical exposure. One patient, a woman, had convulsions and pinpoint pupils, suggesting exposure to a nerve agent.

The Syrian Observatory for Human Rights said at least 80 people were killed in Douma on Saturday, including around 40 who died from suffocation. But it said the suffocations were the result of shelters collapsing on people inside them.

“Until this minute, no one has been able to find out the kind of agent that was used,” said Mahmoud, the White Helmets’ spokesman, in a video statement from Syria.

He said the government was also targeting homes, clinics, and first responder facilities with conventional explosives and barrel bombs. Most of the medical points and ambulances of the town have been put out of service.

Videos posted online by the White Helmets showed victims, including toddlers in diapers, breathing through oxygen masks at makeshift hospitals.

The Syrian government, in a statement posted on the state-run news agency SANA, strongly denied the allegations. It said the claims were “fabrications” by the Army of Islam, calling it a “failed attempt” to impede government advances.

“The army, which is advancing rapidly and with determination, does not need to use any kind of chemical agents,” the statement said.

The Army of Islam was negotiating with Russia, an ally of Damascus, to withdraw its fighters and allow government institutions back into the town, according to the Observatory. An agreement was said to have Russia deploy its military police to take guardianship of the town as Army of Islam fighters handed over their heavy weapons, the group added, but those talks collapsed on Friday, prompting the government to start shelling and bombing Douma indiscriminately.

Hundreds of fighters and their relatives had already left Douma for rebel-held areas in northern Syria.

The alleged gas attack in Douma comes almost exactly a year after a chemical attack in the northern Syrian town of Khan Sheikhoun killed dozens of people. That attack prompted the U.S. to launch several dozen Tomahawk cruise missiles at a Syrian air base. President Donald Trump said the attack was meant to deter further Syrian use of illegal weapons.

U.S. State Department spokeswoman Heather Nauert said that Washington was closely following “disturbing reports” of the alleged chemical weapons attack in Douma.

The Syrian government and its ally, Russia, denied any involvement in the alleged gas attack.

Maj. Gen. Yuri Yevtushenko was quoted by Russian news agencies on Sunday as saying Russia was prepared to send specialists to Douma to “confirm the fabricated nature” of the reports.

Trump is calling for the area to be opened “immediately for medical help and verification. Another humanitarian disaster for no reason whatsoever. SICK!”

The president also appeared to lay blame at the feet of his predecessor, tweeting; “If President Obama had crossed his stated Red Line In The Sand, the Syrian disaster would have ended long ago! Animal Assad would have been history!”

(© Copyright 2017 CBS Broadcasting Inc. All Rights Reserved. The Associated Press contributed to this report.)