LOUISVILLE, Ky. (AP) — Upsets ruled the first three races on the second day of the Breeders’ Cup, with Afleet Again pulling off the biggest surprise at 41-1 odds in the $500,000 Marathon.

Later Saturday, Uncle Mo was the early favorite for the $5 million Classic, with filly Havre de Grace taking on the boys in the showcase race of the two-day world championships.

Goldikova was poised to go for her record fourth consecutive win in the $2 million Mile. Union Rags was the early 2-1 choice in the Juvenile, with the winner likely becoming the early favorite for the Kentucky Derby.

In the Marathon, Afleet Again rallied to win by 2¼ lengths under Cornelio Velasquez. He paid $85.20.

The race was marred by the failure of 3-1 favorite A.U. Miner to finish, along with Meeznah.

Jockey Calvin Borel pulled up A.U. Miner, who fractured the sesimoid bone in his right front leg. Meeznah didn’t finish because of fatigue.

The on-call veterinarian said A.U. Miner was set to have lifesaving surgery next week in Lexington. Dr. Wayne McIlwraith said 60 to 70 percent of horses having such surgery do well.

Ireland-bred Wrote won the $1 million Juvenile Turf by 2¼ lengths, the first victory by a European-based horse during the weekend. The 12-1 shot paid $25.20 to win. It was Irish trainer Aidan O’Brien’s fifth win in the season-ending championships.

Hall of Fame jockey Mike Smith guided Amazombie to a neck victory in the $1.5 million Sprint at 7-1 odds. Smith earned his 14th Breeders’ Cup win, leaving him one behind the record set by retired jockey Jerry Bailey. The 5-year-old gelding paid $17.80 to win.

Order was restored in the $1 million Turf Sprint, with 2-1 favorite Regally Ready winning by 1½ lengths. He ran five furlongs on the turf in 56.48 seconds. Trainer Steve Asmussen and jockey Corey Nakatani earned their second wins of the weekend, having taken the Juvenile Fillies with My Miss Aurelia on Friday.

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